BioOrchestra Biomarker Catalog

Catalog / index layer over the canonical by-photo corpus. This page does not synthesise; it indexes the BioOrchestra biomarker catalog band by stem with provenance links. The chain is a Word navigation-pane alphabetical walk through the BIOMARKER catalog underneath BioOrchestra. Each row is treated as a catalog entry, not an interpretive claim. Where the source carries Uncertain Spans, that uncertainty is preserved here as a per-stem count rather than narrated out.

Bounded scope. This page covers the 74 source pages under the shared nav_path prefix Pipeline of GD & GBA-PD > Supplement > Other Biobanks > Biobanks in Japan > BIOMARKER > BioOrchestra > …, capture-time range 20240722_182708 through 20240722_183115. The Brain Bank / biobank head (_182617_182704) immediately upstream is owned by brain-banks-postmortem (Cluster D). 20240722_183050 (`… > BioOrchestra > Inflammation > ALS > aSyn (therapeutic) antibody

Comorbidity`) is α-synuclein Tier 1 and is owned by alpha-synuclein § Source Table; it is excluded from the catalog below.

Authoring Rules

  • No domain-knowledge corrections. The page reflects what the source notes record (nav_path, source_headings, quality_metrics), not what the field is “supposed” to say.
  • No axis analysis or interpretive prose. Bucket headlines are ≤ 1 sentence and stem-anchored.
  • No prose / interpretation column on the catalog table. Rows carry metadata only (stem, nav leaf, full nav_path, source-note link, canonical link, uncertain-span count, embedded-image count, α-synuclein boundary tag).
  • Uncertain Spans on the source page are preserved as uncertainty counts; cell values, vendor names, contact rosters, GWAS / GPR37 / H&Y / Hearing-loss / Heuron / DLB-vs-PDD-vs-MSA / DATscan / DWI vs DTI / Dyskinesia / EEG / Electrophysiology / Inflammasome catalog rows are not paraphrased.
  • The body of data/processed/markdown/by-photo/ is not modified.
  • No raw photos are staged; no new figure assets added. All 74 source notes report embedded_image_count = 0; this catalog adds none (Build Note, docs/decisions/2026-04-29-body-purity-and-figure-only-embeds.md).
  • α-synuclein content inside this range is referenced by stem only per alpha-synuclein-source-boundary’s borderline rule (“link by stem reference, not table re-quote”). See § α-Synuclein-Adjacent Rows.

Source Boundary / Delegation

This catalog is bounded against multiple sibling owners. Sources outside the 74-page set are linked from this section, not re-narrated on the catalog table.

neighbour clusterstemsowner
α-synuclein Tier 1 inside the BioOrchestra range20240722_183050 (Inflammation > ALS > aSyn (therapeutic) antibody > Comorbidity)alpha-synuclein § Source Table; asyn-propagation-suppressor (programmatic context)
α-synuclein Tier 2 inside the BioOrchestra range (“Brain bank / postmortem aSyn-adjacent”)39 stems per alpha-synuclein-source-boundarythis catalog (rows kept, content not re-narrated); see § α-Synuclein-Adjacent Rows
Brain Bank / biobank head (Cluster D)20240722_18261720240722_182704; 20240722_184200, 20240722_184203brain-banks-postmortem
GBA / GD / GBA-PD biology block (Cluster A)20240722_181813, _182123_182146, _182153_182323gba-pd-biology
GBA / GCase therapeutic-modality cluster (Cluster B)20240722_182326_182419gba-gcase-modalities
α-synuclein supplement chain20240722_182451_182609 aSyn axis rowsalpha-synuclein (Tier 1)
Supplement anatomy chain20240722_182422_182447section-only (gba-pd-asyn)
GBA-PD pilot range20240722_18174820240722_181809gba-pd, gba-therapeutics, biomarkers, eliglustat, ambroxol, venglustat, pr001
Inflammation / Inflammasome thematic contextleaves under BioOrchestra (_183055, _183058, _183101, _183115) sit in this catalog; the broader inflammation section (42 sources) is owned elsewhereinflammation (thematic cross-reference only; rows remain in this catalog)
biomarkers-outcomes whole-section topicsection pages outside gba-pd-asynbiomarkers-outcomes (out of scope)
MSA pagessections/msa (no overlap with BioOrchestra range)msa (out of scope)
samples-collaborations operations / logistics pagessections/samples-collaborationssection-only (out of scope)
PARKN GT cross-filed page20240722_182103 (outside BioOrchestra range)parkn-gt (out of scope)

This page is the residual Cluster C synthesis — the BioOrchestra biomarker-catalog band that brain-banks-postmortem § Source Boundary, gba-pd-biology § Source Boundary, gba-gcase-modalities § Source Boundary, and the alpha-synuclein boundary map borderline rule explicitly delegated to “future Cluster C”. It is not a cross-section topic: all 74 sources sit inside gba-pd-asyn. No new entity pages are created in this pass; vendor / contact / company / consortium / biomarker rows on these 74 source pages remain catalog rows on the canonical by-photo files.

Bucket Index

The 74 sources split into 11 buckets following the leaf segments observed in nav_path (capture-time order). Bucket boundaries follow the leaf word, not the parent prefix; leaves carry the catalog content.

#bucketstemsnleaf range
C0BioOrchestra root_1827081BioOrchestra root (no tail)
C1Blood / PBMC / Vendors_182711, _182715, _1827183Blood, Blood, Vendors of PBMC
C2Braak Staging_182722, _1827252Braak Staging ×2
C3CEI / Cerevance_182728, _182732, _182735, _182738, _182742, _182745, _182749, _182752, _1827559Companies CEI ×4, Summary CEI ×3, Cerevance Deliverables, Cerevance Team
C4Circuits_182758, _1828022Direct pathway, Indirect pathway
C5Dose finding_182805, _182808, _1828113Dose selection/finding, Sample size calculation, Delayed start design
C6Cholinergic alphabetic band_182815, _182818, _182821, _182824, _182827, _182830, _182833, _182836, _182839, _182842, _182845, _182848, _182851, _182854, _182857, _182900, _182904, _182907, _18291019Prevalence → DNA damage (Word-nav alphabetical walk under Cholinergic >)
C7Dopamine system / DAT / Neuromelanin_182913, _182916, _182919, _182922, _182926, _182929, _182932, _182935, _1829389Dopamine metabolites, Summary, Dopa Imaging, DATscan ×2, Rodent Dopamine transporter, Neuromelanin pigment, Neuromelanin-MRI ×2
C8Druggability / DWI-DTI / Dyskinesia → EEG_182941, _182944, _182947, _182950, _1829535Druggability, DWI vs DTI, MOA of Dyskinesia, Pipeline of Dyskinesia, EEG in PD
C9EEG / Electrophysiology / ER / Oligodendrocyte exosome_182956, _182959, _183002, _183006, _183009, _183012, _1830157Effect size ×2, Methods, Process, 4 Exosome, Oligodendrocyte-derived exosome, review (Magrinelli, 2016 #1063)
C10GABA / Gait / Gladstone / GWAS / GPR37 / H&Y / Hearing / Heuron / HR_183018, _183021, _183024, _183028, _183031, _183034, _183037, _183040, _1830449GCS inhibitor, FY22, Summary, LSD genes, H&Y ×2, Hearing loss, HR Performance Review, PET
C11Immunity / Inflammasome / Comorbidity / Inflammation tail_183047, _183055, _183058, _183101, _1831155Imnewrun, In vitro model of neuroinflammation, Imaging neuroinflammation ×2, Markers of microglia

Catalog Source Table

Provenance ground-truth for the 74 sources, in capture-time order.

All rows share the prefix Pipeline of GD & GBA-PD > Supplement > Other Biobanks > Biobanks in Japan > BIOMARKER > BioOrchestra > ; the nav_path column shows the post-BioOrchestra tail only. The BioOrchestra root row (_182708) has an empty tail. The aSyn column carries T2 for stems classified “Brain bank / postmortem aSyn-adjacent” Tier 2 in alpha-synuclein-source-boundary; otherwise . _183050 is α-synuclein Tier 1 and is not in this table; see § Source Boundary / Delegation.

stemnav leafnav_path tail (after BioOrchestra >)source notecanonicaluncertainembedsaSyn
20240722_182708BioOrchestra(root, no tail)notemd00T2
20240722_182711BloodBloodnotemd40
20240722_182715BloodBloodnotemd30
20240722_182718Vendors of PBMCBlood > PBMC > Vendors of PBMCnotemd20T2
20240722_182722Braak StagingBraak Stagingnotemd10T2
20240722_182725Braak StagingBraak Stagingnotemd30T2
20240722_182728Companies CEICEI > Companies CEInotemd20T2
20240722_182732Companies CEICEI > Companies CEInotemd20T2
20240722_182735Companies CEICEI > Companies CEInotemd30T2
20240722_182738Companies CEICEI > Companies CEInotemd20T2
20240722_182742Summary CEICEI > Summary CEInotemd30T2
20240722_182745Summary CEICEI > Summary CEInotemd10T2
20240722_182749Summary CEICEI > Summary CEInotemd20T2
20240722_182752DeliverablesCEI > Cerevance > Deliverablesnotemd20
20240722_182755TeamCEI > Cerevance > Teamnotemd20
20240722_182758Direct pathwayCircuits > Direct pathwaynotemd10
20240722_182802Indirect pathwayCircuits > Indirect pathwaynotemd10
20240722_182805Dose selection/findingDose finding > Dose selection/findingnotemd20
20240722_182808Sample size calculationDose finding > Sample size calculationnotemd30T2
20240722_182811Delayed start designDose finding > Delayed start designnotemd30
20240722_182815PrevalenceCholinergic > Prevalencenotemd30
20240722_182818vMRICholinergic > vMRInotemd20T2
20240722_182821PathologyCholinergic > Pathologynotemd30T2
20240722_182824ConsortiumCholinergic > Consortiumnotemd20
20240722_182827ConsortiumCholinergic > Consortiumnotemd10T2
20240722_182830ContactsCholinergic > Contactsnotemd10T2
20240722_182833CSFCholinergic > CSFnotemd20T2
20240722_182836CSF FlowCholinergic > CSF Flownotemd00T2
20240722_182839Human CSF samplingCholinergic > Human CSF samplingnotemd30
20240722_182842interferon-stimulated geneCholinergic > Interferons > interferon-stimulated genenotemd30
20240722_182845Multiplex cytokine assayCholinergic > Multiplex cytokine assaynotemd00
20240722_182848Diagnosis of PDCholinergic > Diagnosis of PDnotemd00
20240722_182851Digital TrialsCholinergic > Digital Trialsnotemd10
20240722_182854Digital TrialsCholinergic > Digital Trialsnotemd00
20240722_182857Digital TrialsCholinergic > Digital Trialsnotemd00T2
20240722_182900Disease area TM strategyCholinergic > Disease area TM strategynotemd10T2
20240722_182904DLB vs PDD vs MSACholinergic > DLB vs PDD vs MSAnotemd10T2
20240722_182907DLB vs PDD vs MSACholinergic > DLB vs PDD vs MSAnotemd00T2
20240722_182910DNA damageCholinergic > DNA damagenotemd00T2
20240722_182913Dopamine metabolites in PDDopamine system > Dopamine metabolites in PDnotemd10
20240722_182916Summary of dopamine systemDopamine system > Summary of dopamine systemnotemd00
20240722_182919Dopa ImagingDopamine system > Dopa Imagingnotemd00T2
20240722_182922DATscan in PDDopamine transporter Imaging > DATscan in PDnotemd10
20240722_182926DATscan in PDDopamine transporter Imaging > DATscan in PDnotemd20
20240722_182929Rodent Dopamine transporterDopamine transporter Imaging > Rodent Dopamine transporternotemd10
20240722_182932Neuromelanin pigmentDopamine system > Neuromelanin pigmentnotemd00T2
20240722_182935Neuromelanin-MRIDopamine system > Neuromelanin-MRInotemd00
20240722_182938Neuromelanin-MRIDopamine system > Neuromelanin-MRInotemd00
20240722_182941DruggabilityDruggabilitynotemd00
20240722_182944DWI vs DTIDruggability > DWI vs DTInotemd30
20240722_182947MOA of DyskinesiaDruggability > DWI vs DTI > Dyskinesia > Clinical presentation of Dyskinesia in PD > MOA of Dyskinesianotemd20
20240722_182950Pipeline of DyskinesiaDruggability > DWI vs DTI > Dyskinesia > Clinical presentation of Dyskinesia in PD > MOA of Dyskinesia > Outcome Measures Dyskinesia > Animal models of Dyskinesia > Pipeline of Dyskinesianotemd30
20240722_182953EEG in PDDruggability > DWI vs DTI > Dyskinesia > Pipeline of Dyskinesia > EEG > Bands > EEG in PDnotemd20
20240722_182956Effect sizeEEG > Bands > EEG in PD > Limitations > Sleep EEG > Effect sizenotemd30
20240722_182959Effect sizeEEG > EEG in PD > Limitations > Sleep EEG > Effect sizenotemd50
20240722_183002MethodsEEG > Effect size > Efficacy modelling > Electrophysiology > Anatomy of a neuron > Methodsnotemd10T2
20240722_183006ProcessElectrophysiology > Anatomy of a neuron > Methods > Resting potential (Inactive state) > Processnotemd20T2
20240722_1830094 ExosomeElectrophysiology > Process > voltage-dependent ion channels > ERB > Endoplasmic Reticulum (ER) > 4 Exosomenotemd10T2
20240722_183012Oligodendrocyte-derived exosomeEndoplasmic Reticulum (ER) > 4 Exosome > ConsoRCC > Example > 4 NDE > neuronal exosome enrichment procedure > Oligodendrocyte-derived exosomenotemd30T2
20240722_183015review (Magrinelli, 2016 #1063)Oligodendrocyte-derived exosome > Eye > Fibroblast > Cell model system for CNS? > GABA > Further readings > GABA imaging > review (Magrinelli, 2016 #1063)notemd30T2
20240722_183018GCS inhibitorGABA imaging > Gait > 4 Gait > Assessment of Gait > Galectin-3 > GCS inhibitornotemd30T2
20240722_183021FY22Gladstone Institute > Glutamate > Imaging > Goals > FY22notemd40T2
20240722_183024SummaryGoals > FY22 > GWAS > Modifiers > Summarynotemd50T2
20240722_183028LSD genesGWAS > Modifiers > Summary > LSD genesnotemd40T2
20240722_183031H&Y (Hoehn and Yahr)GWAS > Summary > LSD genes > GPR37 > Glossary > H&Y (Hoehn and Yahr)notemd40
20240722_183034H&Y (Hoehn and Yahr)GPR37 > Glossary > H&Y (Hoehn and Yahr)notemd40
20240722_183037Hearing lossH&Y (Hoehn and Yahr) > HA-tag > Hearing lossnotemd20
20240722_183040HR Performance Review (including 360)Hearing loss > Heuron > Hirozane, Yoshihiko > HR Performance Review (including 360)notemd30T2
20240722_183044PETHR Performance Review (including 360) > Human Biological Samples > Imaging > PETnotemd40
20240722_183047ImnewrunImmunity > Autoimmunity (Autoantibody) > Evidence > ImmunoPET > Imnewrunnotemd20T2
20240722_183055In vitro model of neuroinflammationComorbidity > Signals > Inflammasome > In vitro model of neuroinflammationnotemd20
20240722_183058Imaging neuroinflammationInflammasome > In vitro model of neuroinflammation > Imaging neuroinflammationnotemd30T2
20240722_183101Imaging neuroinflammationInflammasome > In vitro model of neuroinflammation > Imaging neuroinflammationnotemd30T2
20240722_183115Markers of microgliaInflammasome > In vitro model of neuroinflammation > Imaging neuroinflammation > Structure of microglia > Phenotypes of microglia > Markers of microglianotemd30T2

Totals across the 74 sources: uncertain_span_count = 144; embedded_image_count = 0. α-synuclein Tier 2 tag = 39 stems.

Per-bucket subtotals:

bucketnuncertainembedsT2T1 / T3
C0 BioOrchestra root1001
C1 Blood / PBMC / Vendors3901
C2 Braak Staging2402
C3 CEI / Cerevance91907
C4 Circuits2200
C5 Dose finding3801
C6 Cholinergic alphabetic band1923011
C7 Dopamine system / DAT / Neuromelanin9502
C8 Druggability / DWI-DTI / Dyskinesia → EEG51000
C9 EEG / Electrophysiology / ER / Oligodendrocyte exosome71805
C10 GABA / Gait / Gladstone / GWAS / GPR37 / H&Y / Hearing / Heuron / HR93305
C11 Immunity / Inflammasome / Comorbidity / Inflammation tail51304
total74144039

Numbers are review surface area, not resolutions. The per-stem uncertain_span_count and embedded_image_count come from the source notes’ quality_metrics block; downstream extractors should treat the canonical by-photo cell values as the source of truth rather than this catalog page.

α-Synuclein-Adjacent Rows

The 39 stems below are tagged “Brain bank / postmortem aSyn-adjacent” Tier 2 in alpha-synuclein-source-boundary § Tier 2. They remain catalog rows on this page; α-synuclein content on these pages is not re-narrated here. The α-synuclein synthesis (alpha-synuclein) already references these by stem rather than by table re-quote. The boundary map’s borderline-rule note flags 20240722_182722 (Masuda-Suzukake α-syn fibrils, propagation / Braak / Cholinergic block) as a candidate for promotion to Tier 1 if the body is re-checked; this is not done in the current pass.

stemnav leafaSyn boundary tagsource notecanonical
20240722_182708BioOrchestraBrain bank / postmortem aSyn-adjacent (T2)notemd
20240722_182718Vendors of PBMCT2notemd
20240722_182722Braak StagingT2 (Tier 1 promotion candidate per boundary map)notemd
20240722_182725Braak StagingT2notemd
20240722_182728Companies CEIT2notemd
20240722_182732Companies CEIT2notemd
20240722_182735Companies CEIT2notemd
20240722_182738Companies CEIT2notemd
20240722_182742Summary CEIT2notemd
20240722_182745Summary CEIT2notemd
20240722_182749Summary CEIT2notemd
20240722_182808Sample size calculationT2notemd
20240722_182818vMRIT2notemd
20240722_182821PathologyT2notemd
20240722_182827ConsortiumT2notemd
20240722_182830ContactsT2notemd
20240722_182833CSFT2notemd
20240722_182836CSF FlowT2notemd
20240722_182857Digital TrialsT2notemd
20240722_182900Disease area TM strategyT2notemd
20240722_182904DLB vs PDD vs MSAT2notemd
20240722_182907DLB vs PDD vs MSAT2notemd
20240722_182910DNA damageT2notemd
20240722_182919Dopa ImagingT2notemd
20240722_182932Neuromelanin pigmentT2notemd
20240722_183002MethodsT2notemd
20240722_183006ProcessT2notemd
20240722_1830094 ExosomeT2notemd
20240722_183012Oligodendrocyte-derived exosomeT2notemd
20240722_183015review (Magrinelli, 2016 #1063)T2notemd
20240722_183018GCS inhibitorT2notemd
20240722_183021FY22T2notemd
20240722_183024SummaryT2notemd
20240722_183028LSD genesT2notemd
20240722_183040HR Performance Review (including 360)T2notemd
20240722_183047ImnewrunT2notemd
20240722_183058Imaging neuroinflammationT2notemd
20240722_183101Imaging neuroinflammationT2notemd
20240722_183115Markers of microgliaT2notemd

α-synuclein Tier 1 content inside the BioOrchestra range — the single page 20240722_183050 (Inflammation > ALS > aSyn (therapeutic) antibody > Comorbidity) — is not in this catalog. It is owned by alpha-synuclein § Source Table and is referenced in alpha-synuclein § “Antibody and Immunotherapy Programs” / “aSyn (therapeutic) antibody”. This catalog only acknowledges the row’s existence at § Source Boundary / Delegation; downstream readers who want the page’s content should follow the α-synuclein topic.

Uncertainties Carried Forward

Per-stem uncertain-span counts are in the Catalog Source Table above; totals appear in the per-bucket subtotal table. Highlights worth checking before downstream extraction (no content is paraphrased on this page; open the canonical page for cell values):

  • EEG / Sleep EEG / Effect size hot spot. 20240722_182959 carries 5 uncertain spans, the densest stem in this catalog (md). Adjacent stems on the EEG band (_182956, _183002) carry 3 and 1 respectively.
  • GWAS / Modifiers / Summary band. 20240722_183024 carries 5 uncertain spans (md); adjacent stems _183021 (FY22), _183028 (LSD genes), _183031 (H&Y), _183034 (H&Y) each carry 4. The Goals > FY22 > GWAS > Modifiers > Summary > LSD genes > GPR37 > Glossary > H&Y walking chain accumulates uncertainty across nearly every stem.
  • Blood / PBMC opener. _182711 carries 4 uncertain spans, the densest C1 entry (md).
  • HR Performance Review / Human Biological Samples / Imaging / PET catalog tail. _183044 carries 4 uncertain spans (md); the surrounding HR / Human Biological Samples / Imaging walk records mixed contact / process / vendor cells.
  • Druggability / DWI-DTI / Dyskinesia walk. _182944, _182947, _182950, _182953 carry 3, 2, 3, 2 uncertain spans respectively. The Dyskinesia subtree (Clinical presentation → MOA → Outcome Measures → Animal models → Pipeline) is a long single-thread inherited nav_path; cell values across the chain are review targets.
  • Inflammasome / Imaging neuroinflammation / Microglia tail. _183058, _183101, _183115 carry 3 each. _183115 carries the Structure of microglia > Phenotypes of microglia > Markers of microglia deepest leaf in the catalog.
  • 0-uncertain-span rows. 14 of 74 stems report 0 uncertain spans in source-note frontmatter (_182708, _182836, _182845, _182848, _182854, _182857, _182907, _182910, _182916, _182919, _182932, _182935, _182938, _182941). These are typically catalog / process / vendor / contact-list pages whose dense matrix cell content is on the canonical page; downstream extractors should still treat the canonical cells as authoritative rather than infer from the 0 count.
  • BIOMARKER → BioOrchestra boundary. This catalog opens at _182708 immediately after the BIOMARKER tracker bridge tail (_182704) owned by brain-banks-postmortem. The BIOMARKER axis spans both Cluster D (sample-side bridge) and this Cluster C (BioOrchestra catalog body); cell values on the BIOMARKER tracker matrix that overlap both pages are preserved verbatim on the canonical pages.
  • α-synuclein Tier 1 link to _183050. The single Tier 1 page inside the BioOrchestra range is excluded from this catalog and owned by alpha-synuclein; see § α-Synuclein- Adjacent Rows for the boundary statement.