Cerevance Team table (full), Centrifuge / ultracentrifuge note (Olga), Ceri Davies / Christine Klein meeting block, Mitochondrial biomarkers mini-table, Circuits / Direct pathway (cortex → striatum → SNc / GPe / GPi/SNr / STN → thalamus diagrams)

Team

Function	Team member
Deal lead	David Kim
PM	Raj McLaren
Clin Sci	Arthur Simen
Clin Ops	Nancy Goodman
Regulatory	Emmanuelle Magueur
Stats	Sudipta Bhattacharya
Quantitative Clinical Pharmacology	Lin Xu
Translational Medicine	Lee, Jaewon
Translational Medicine - Biomarkers	Stephen Zicha
Medical Safety/PV	in process
Outcomes	in process
DSRE	Ravikumar Peri
DMPK	Mi-Sook Kim
DDU	Robert Hodgson (Sandy)
GMS/PS	Nathan Geething, Andrew Kroetsch
GQ	Ian King
GPLS	Joseph, Yassir
GPLS Pricing and Access	Elizabeth Kinter
US Commerical	Sara Sarkey, Minal Narveka, Katie Strzalka, Carl Libardoni
Med Affrs	Daniel Sindelar Barczak
IP	in process
Legal	Pete Brigida
Tax	Wayne Jenner (Jake will organize)
BD Finance	Jake Fulham
Accounting	Greg Block (Jake will organize)
AM	TBD

	centrifuge	ultracentrifuge
speed		~1,000,000 g (approx. 9,800 km/s²), Even smaller particles
separation	Particles of ≤5 uM, ii) inflammasome: ~0.45 uM in diameter (~700 kDa), Olga: A typical standard procedure in a trial is to centrifuge CSF briefly after collection, at slow speed; just to remove cell debris etc: This accommodates most soluble biomarkers we would want to look at, but I suppose no centrifugation could be accommodated if really needed, however - I am more concerned in your case in how reliable the measurement is if it goes away with even very mild centrifugation and whether or not the signal comes from just debris and is not biologically relevant. in vitro 에서 specificity 의 증명할 방법이 없으니, 이 signal 이 debris 에서 나온 것 아니냐?--> human CSF sample 으 까지 characterization 해도 이거 됨 ( 외 안 되냐?) Typically purification of oligomeric/fibrillar species from biomaterials such as even brain lysates requires super high centrifugation speeds for prolonged periods of time so I am a bit suspicious here.

20210531 meeting

	Novel Mitochondrial Biomarkers in Genetically Stratified Parkinson's Disease Patients
MP, Blood cells
coQ10, P MRS	Preclinical validation?

overall, stimulate thalamus and thus cortex (외우는 법: 서스지쌀코, 이중 스지 가 inhibitor)
↑ SNc → ↑ D1 MSNs in striatum → (↑ GABA release onto GP) → ↓ [Gpi & SNR] (SNc 아니니 혼동말자) → thalamus 를 억제하는 Gpi 를 억제하므로 thalamus 자극됨 → ↑ cortex 자극 → ↑ movement.

아래 그림은 정상적인 direct pathway

PD 에서는 위 과정이 반대로 됨, 그런데 Ach interneurons are still inhibiting the striatal cells. (2012 #2007) 위 그림 보면 아래의 ‘이 선 blue’ 는 오기가 아님을 알 수 있음.

이 선 blue 의 오기?

location	transcription	uncertainty
Anatomical diagram / Motor Cortex row	`LEFT` / `RIGHT` headers above the diagram	the LEFT side panel is mostly blank in the visible crop; only the RIGHT side carries the labelled diagram; preserved as visible.