Heuron

• Their flagship technology is nigrosome1 MRI. Nigrosome1 is a small structure in the midbrain and PD its intensity in MRI is changed due to the loss of melanin-containing neurons. Its quantitiation is somewhat challenging to standardize and they are using AI to distinguish PD patients from normal people. They are now trying to validate this with clinically-based PD diagnosis by a clinical study (N=221). However, at this stage, I doubt its utility for our translational or clinical works since we already have good clinical imaging modalities that have good diagnostic power and longitudinal effect size when they have been assessed longitudinally.

• Nigrosome1 MRI,

  • Cross-sectional

• NCT04334902

  • Validation against 18F FP-CIT PET/CT

• Questions

  • Longitudinal trajectory, effect size?
  • Currently better than DATScan?
  • Your dat imaing vs DATScan?

• 20201117

  • NIGROSOME1 : is subregion of SNpc
  • Nigrosome1 MRI: QUALItative! Quantification not feasible
  • Clinical trial: validate (병 유무의 이분법을) against clinical diagnosis, DATscan

• 20201202

Hirozane, Yoshihiko

• GBA Activator MBM TR
  • You lead? Like in MAPT-HDO project?
• Tottori
  • Who leads?
    • Who talks to Prof. Narita?
  • Objective?
    • How to validate?
  • Assay?
    • DMPK 가 SET up 한 GlcCer, GlcSph assay 가져다 쓸건가?
    • aSyn
  • Not in PD?
• NHP model
  • Who will do?
  • DMPK 가 SET up 한 GlcCer, GlcSph assay 가져다 쓸건가?
  • 약 test 한다면 ARNU 에서 약 대여하나? Tau 도 그럴건가?
• aSyn
  • existing vs ADx Neurosciences : oligomeric (German company, 3D5), p-aSyn (pS129 a-syn polyclonal an-tibody (Santa Cruz),

HR Performance Review (including 360)

Achievement	Achieves optimal levels of performance and accomplishment with / for ... Provides strong evidence of [specific accomplishment] Excels at developing programs / strategies that have delivered X results Improved production by X% through [specific task] Exceeded the original goal of X by X% through [specific task]
Administration	Continuously examines administrative effectiveness and seeks better procedures such as [tasks] Develops successful administrative strategies such as [task] that led to [results] Establishes effective systems for information retrieval through [task] Improves administrative support systems through [task] Keeps documents organized via [task] to avoid duplicate information
Communication Skillsa	Effectively communicates expectations Excels in facilitating group discussions Keeps meetings action-oriented by task Effectively communicates upward, downward, and laterally Enforces company policies and values without creating negative reactions Transparent with Positive attitude
Cooperation	Encourages collaboration with the team Shares ideas and techniques
Creativity	Builds strong relationships with others by [task] Displays a harmonious and cooperative spirit by [task] Gladly shares expertise Seeks creative alternatives such as [examples] that drove [results] Clever and imaginative when confronted with obstacles Is continuously experimenting to drive [results] Initiates and executes creative ideas such as [example] Seeks new ideas and approaches
Improvement	Develops continuous improvement methods Conceives of totally new strategies Continues to grow and improve Devises improved means of accomplishing results Is continuously planning for improvement
Interpersonal Skills	Recognizes the needs of others and reaches out to lend a helping hand Establishes effective working relationships Generates synergy Builds on mutual dependence and understanding Promotes the company culture among peers
Planning	Develops workable action plans Creates flexible plans to meet changing opportunities Effectively puts plans into action Excels in developing strategic alternatives Formulates strategies, tactics, and action plans to drive X results
potential	Is capable of distinguished performance in a higher-level position Has reached the level for promotional consideration Can handle bigger projects and assignments Is making a strong effort to acquire greater experience and skills to increase potential for advancement Is enhancing growth potential through additional education and training
Problem-Solving	Displays a practical approach to solving problems Develops creative solutions Turns problems into opportunities Effectively solves problems rather than symptoms Is skilled in proposing optional solutions
Project Management	Completed X project with X results Sets realistic timetables to keep projects on target Makes effective use of all available resources when given a project Clearly establishes project goals and objectives
Time Management	Consistently meets all deadlines Prepares meeting agendas that are concise and time-saving Keeps meetings on schedule Respects the time of others Makes effective use of discretionary time

Human Biological Samples

A company-wide HBS Policy and SOP is being created. Until then, the new process is as follows:

ve immediately, we will be using the Scientist.com platform for HBS; the ability to order HBS as catalog items in Ariba is no longer available. For definition,

n Biological Samples include but not limited to:

• Human tissue—fresh, frozen, fixed or processed (e.g., sectioned)
• All human blood (e.g., peripheral or umbilical cord) and blood byproducts (e.g, serum, plasma, buffy coat)
• All human biofluids (e.g., sputum, urine, bile)
• Human primary cells derived from human biosamples

Scientists are responsible for:

1. Submitting requests for HBS using the Scientist.com platform. Please make every effort to work with already approved HBS suppliers there.

Uncertain Spans

location	transcription	uncertainty
Heuron / 20201202 entry	the dated bullet 20201202 is followed by a single empty o indent marker; preserved verbatim.	source bullet appears intentionally empty at the visible window.
Hirozane, Yoshihiko / NHP model / 약 test 한다면 ARNU 에서 약 대여하나	reads 약 test 한다면 ARNU 에서 약 대여하나? Tau 도 그럴건가?; preserved verbatim.	low confidence on ARNU proper noun.
HR Performance Review header	the section title in source includes a + toggle glyph: K +erformance Review (including 360) (visible as K Berformance in body_full); preserved verbatim as HR Performance Review (including 360) matching the side-nav bleed.	low confidence on glyph at column origin.