Source 20240722_182935

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Page labelPage 498 of 504
Navigation pathPipeline of GD & GBA-PD > Supplement > Other Biobanks > Biobanks in Japan > BIOMARKER > BioOrchestra > Dopamine system > Neuromelanin-MRI
SectionGBA-PD, GD, and α-Synuclein Pipeline
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Headings

  • Neuromelanin pigment biochemistry (Zecca review caption: NM-pigment biosynthesis & NM-containing organelle formation in human SN), Function (chelate iron / pigmented neurons vs TH correlation, Mor 2008 #1643), Rodent vs NHP, Neuromelanin-MRI section opener (Principle Sulzer 2018 #1597 / Iron in non-pigmented cells / SN pars reticulata, globus pallidus, caudate nucleus), METHODS (T1-weighted FSE / voxelwise NM-MRI / test-retest), Cassidy 2019 #1595 validation studies opener (NM-MRI vs neuromelanin tissue concentration / dopamine release / neural activity / clinical severity)
  • Function
  • Rodent
  • Neuromelanin-MRI
  • Principle
  • METHODS
  • validation (Cassidy, 2019 #1595)

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