Correlation / Exact test (continued)

r	α	β	tail	Exact test	N needed to achieve statistical significance
0.5	0.1	0.7	One		13
0.5	0.1	0.8	one		17
	0.05	0.8	one
	0.1	0.7	one
	0.1	0.7	one
	0.1	0.8	one
0.5	0.05	0.8	one		23
0.5	0.05	0.7	one		18
0.5	0.05	0.7	two		23
0.5	0.05	0.8	two		29
0.6	0.1	0.7	two		12
0.6	0.1	0.8	Two		15
	0.05	0.8	Two
	0.1	0.7	One
	0.1	0.7	One
	0.1	0.8	One
0.6	0.05	0.8	Two		19
0.6	0.05	0.7	two		15
	0.1	0.7	One
	0.1	0.7	One
	0.1	0.7	One
	0.1	0.7	One
	0.1	0.7	One

Efficacy modelling

disease progression model	Item Response Theory (IRT) analysis of MDS-UPDRS	We modeled MDS-UPDRS data in PPMI data base, and these subjects are not on treatment	Hang, Yaming <[email protected]>: Clinical Pharmacology, (part of QTS)
semi-mechanistic model	we are building a of PD. The primary objective is to link dopamine decline to modulation of downstream biomarkers, such se gabergic and gltaminergic signals, and ultimately map this into changes in UPDRS 'Parkinson_Takeda_21MAY2021_v3.pptx '(중요) Sergio Iadevaia, Ph.D. [email protected] Scientific Director of QSP (Quantiatative Systems Pharmacology, probably part of QTS), Pharmacometrics and Machine Learning, Quantitative Solutions @ Takeda Pharmaceuticals, 350 Massachusetts Ave, Cambridge, MA 02139 Office: 617-551-3818	Univ. of Florida collaboration (지도교수: Dr. Valvanera Vozmediano, [email protected])	[email protected] 김채진	6 cluster is correct. but the graph below has only 5 clusters by mistake. cluster 5 is distinct (rapid progressor, they show low putamen SRB, LOW SBR RAtio?). baseline SBR 잇ㅆ으면 어떤 CLUSTER 인지 예측 가능하게 하려함. BUT variability 가 현재 문제임 next step: validation cohort 필요.
			Vijay Kumar Siripuram, PhD	Longitudinal GABA imaging 이 도움 될 듯, Putamen 손상이 caudate 손상보다 comes early, suggesting that putamen is responsible for motor Sx, and caudate is responsible for non-motor Sx. → ↑ striatal GABA data 확인 필요함 (using i) asking VIJAY ii) Pfizer data.
Meeting 20220301	QS is organizing this discussion forum (Dipak Barua, Associate Scientific Director, Quantitative Solutions) https://mytakeda-my.sharepoint.com/:v:/r/personal/dipak_barua_takeda_com/Documents/Recordings/Scientific%20discussion%20forum%20on%20Parkinson%27s%20disease%20modeling-20220228_150134-Meeting%20Recording.mp4?csf=1&web=1&e=msLOFH 아마 35분 째부터, Vijay Kumar Siripuram, PhD
memo	Aim to see >?% KD of SNCA	MEDI-1341→ ↓(~50%) aSyn spreading -→ cosequence? Eg. Neuroprotection? Behavior? Aim to see >?% KD of SNCA : p-aSyn 이 주축이 되어야 하지 않나? {Lue, 2012 #1372} 에 보면 p-aSyn 이 olf bulb only stage 에선 0 인데... 우리가 할 수 있나? Methods: -Atuka: p-aSy 확실히 생기는데, SZ 의 Update 요청하자. - patient postmortem: paper 더 찾s 아보자. -rodent: PFF model 로 가능한가? 大 characterisation 한 논문을 찾아보자 (motor symptom , 등도 같이 본 논문이 있긴 하나, 이것 neurodegeneration 정도와 같이 temporal characterisation 한 논문을 찾는 것이 도움 들 듯) - to work with Jonghun ?

Electrophysiology

Anatomy of a neuron

• Myelinated section: no action potential generated due to the lack of channels on the surface of axons
• Node of ranvier: antion potential generated
• Axon terminal : action potential generated → neurotransmitter released

Methods

	protocol	Disadvantage	subtype
membrane channel function			Artificial membrane-channel preparation
			Single-channel patch clamp
			Whole-cell clamp
cellular electrical fundtion			Voltage and Ion-Sensitive Dyes and Resins
			Isolated Neurons and Neuronal Cultures
slices to study al circuit function		Neurons in the slide lack normal afferent inputs and efferent targets, and circulating influences like hormens or steroid, results may be heavily biased by the particular experimental conditions employed in an individual lab (		Hippocmapl slide	LTP, postsynaptic effects of various transmitters at the membrane level,

Uncertain Spans

location	transcription	uncertainty
Methods / slices / al circuit function	left column reads slices to study al circuit function (sic, likely a clip of neural circuit function).	source/edge clip.