Inflammation / NLRP3 / Pyroptosis / Complement

Sources covering the Pipeline of Inflammation arc: NLRP3 structure / toxicity / Tx, NLRP3 inhibitor (Marianthi, PFR-4231-100), CAPS, pyroptosis MOA and assays, inflammasome / interferon / cytokine omics, Complement / C5aR1 (Woodruff), Havrda, In Vivo strategy (Katy), and 4 LPS.

Source-of-truth pages live in data/processed/markdown/by-photo/. Each row below points first to the KB source note (which carries the heading list) and then to the canonical transcription.

Sources in this section: 42

Top-level nav clusters: 19

Pipeline of Inflammation

14 source pages

photo	page	nav path	source note	transcription
20240722_183121	Page 626 of 632	Pipeline of Inflammation > Pyroptosis MOA > Pyroptosis evidence/MOA/Correction in PD	note	md
20240722_183125	Page 651 of 660	Pipeline of Inflammation > Pyroptosis MOA	note	md
20240722_183128	Page 651 of 660	Pipeline of Inflammation > Pyroptosis MOA > Pyroptosis evidence/MOA	note	md
20240722_183141	Page 661 of 670	Pipeline of Inflammation > CAPS > WBC > Dx > ARP > Sx	note	md
20240722_183153	Page 661 of 670	Pipeline of Inflammation > Pipeline CAPS > Animal model > TM > NLRP3 inhibitor (Marianthi) (PFR-4231-100)	note	md
20240722_183206	Page 695 of 701	Pipeline of Inflammation > Pipeline CAPS > NLRP3 inhibitor (Marianthi) (PFR-4231-100) > AD > Assays of pyroptosis	note	md
20240722_183218	Page 698 of 704	Pipeline of Inflammation > NLRP3 inhibitor (Marianthi) > AD > Chemistry > Clinical > Comp Bio > Competitor	note	md
20240722_183231	Page 713 of 719	Pipeline of Inflammation > NLRP3 inhibitor (Marianthi) > In Vivo strategy > Havrda > HED > IHC	note	md
20240722_183244	Page 733 of 738	Pipeline of Inflammation > NLRP3 inhibitor (Marianthi) > Katy > Longitudinal > Metabolomics > Microglial Imaging	note	md
20240722_183255	Page 744 of 750	Pipeline of Inflammation > NLRP3 inhibitor (Marianthi) > Microglial Imaging > NHP > PDE > PE > PET	note	md
20240722_183308	Page 747 of 753	Pipeline of Inflammation > NLRP3 inhibitor (Marianthi) > PK/PD > PK/PD Strategy > Postmortem > Proteina	note	md
20240722_183321	Page 765 of 776	Pipeline of Inflammation > NLRP3 inhibitor (Marianthi) > Reactome > Safety > Screening flow > ShareFolder	note	md
20240722_183335	Page 782 of 789	Pipeline of Inflammation > Complement / C5aR1 > MOA > Woodruff’s study plan > Screening > DD	note	md
20240722_183348	Page 792 of 798	Pipeline of Inflammation > Postmortem > Imaging of Iron > IT > Jaya	note	md

Inflammation

5 source pages

photo	page	nav path	source note	transcription
20240722_183147	Page 661 of 670	Inflammation > NLRP3 > Tx	note	md
20240722_183159	Page 661 of 670	Inflammation > NLRP3 inhibitor (Marianthi) > AD > Assays of pyroptosis	note	md
20240722_183225	Page 713 of 719	Inflammation > Competitor > Havrda	note	md
20240722_183238	Page 726 of 732	Inflammation > In Vivo strategy > Katy	note	md
20240722_184357	Page 1036 of 1044	Inflammation > 기타 MOA들 > Pittsburgh University > Greenamyre Lab	note	md

Assays of pyroptosis

2 source pages

photo	page	nav path	source note	transcription
20240722_183203	Page 695 of 701	Assays of pyroptosis	note	md
20240722_183208	Page 698 of 704	Assays of pyroptosis > Budget & FTE > Ceri > Chemistry	note	md

Imaging neuroinflammation

2 source pages

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20240722_183104	Page 626 of 632	Imaging neuroinflammation	note	md
20240722_183108	Page 626 of 632	Imaging neuroinflammation > DPA714 > 3rd Generation TSPO	note	md

In Vivo strategy

2 source pages

photo	page	nav path	source note	transcription
20240722_183234	Page 713 of 719	In Vivo strategy > Katy	note	md
20240722_183241	Page 726 of 732	In Vivo strategy > Katy > Longitudinal	note	md

NLRP3

2 source pages

photo	page	nav path	source note	transcription
20240722_183132	Page 661 of 670	NLRP3 > Structure	note	md
20240722_183144	Page 661 of 670	NLRP3 > Toxicity	note	md

NLRP3 inhibitor (Marianthi) (P…)

2 source pages

photo	page	nav path	source note	transcription
20240722_183156	Page 661 of 670	NLRP3 inhibitor (Marianthi) (P…) > AD > Assays of pyroptosis	note	md
20240722_183222		NLRP3 inhibitor (Marianthi) (P…) > Pipeline / Competitors	note	md

Stratification strategy on…

2 source pages

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20240722_183521	Page 882 of 889	Stratification strategy on…	note	md
20240722_184310	Page 984 of 994	Stratification strategy on… > Pathogenicity of variant	note	md

[GT]

1 source page

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20240722_184743	Page 1256 of 1262	[GT] > AAV > Capsid (serotype)	note	md

Assays of pyroptosis (cytokine / chemokine omics)

1 source page

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20240722_183215	Page 698 of 704	Assays of pyroptosis (cytokine / chemokine omics) > AD	note	md

Background

1 source page

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20240722_183342	Page 788 of 796	Background > Pipeline C5aR1 > Innomedica (Haven) > In Vivo Clibration	note	md

Comp Bio

1 source page

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20240722_183212	Page 698 of 704	Comp Bio	note	md

Cryopyrin-Associated Periodic Syndromes (CAPS)

1 source page

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20240722_183138	Page 661 of 670	Cryopyrin-Associated Periodic Syndromes (CAPS)	note	md

Havrda

1 source page

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20240722_183228	Page 713 of 719	Havrda	note	md

Minee Choi

1 source page

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20240722_183354	Page 798 of 805	Minee Choi > Kv1.3 > Kyoko Yoshikawa > Lee Jonghun	note	md

Pipeline CAPS

1 source page

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20240722_183150	Page 661 of 670	Pipeline CAPS	note	md

Pyroptosis evidence/MOA…

1 source page

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20240722_183351	Page 798 of 805	Pyroptosis evidence/MOA…	note	md

Pyroptosis MOA

1 source page

photo	page	nav path	source note	transcription
20240722_183118	Page 626 of 632	Pyroptosis MOA	note	md

Stratification strategy on neuroinflammation

1 source page

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20240722_183332	Page 779 of 784	Stratification strategy on neuroinflammation > RNA-Seq (Daria) > C5aR1 (Woodruff, Univ of Queensland)	note	md

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