xlix) no nigral iron changes (Dexter et al. 1992) have been found in pre-symptomatic PD or incidental Lewy body disease (although this has been disputed, in Braak I/II) or mild PD (Riederer et al. 1989).
Postmortem
{Wang, 2016 #1591} metaanalysis
Postmortem
R2*
SWI
Change
p
n
Change
p
n
Change
p
n
Substantia nigra
↑
0.01
173
↑
<10⁻⁵
631
↑
<10⁻⁴
465
↑a
0.004
161
↑a
<10⁻⁵
556
Putamen
↑
0.002
100
—
0.74
446
↑
0.04
431
↑a
0.001
371
Globus pallidus
—
0.72
104
—
0.37
500
—
0.20
431
↑a
<10⁻⁴
396
Nucleus caudatus
—
0.47
117
—
0.80
437
↑
0.0003
431
Frontal lobe
—
0.33
98
NA
NA
NA
NA
NA
NA
Temporal lobe
—
0.11
44
NA
NA
NA
NA
NA
NA
Cerebellum
—
0.14
58
NA
NA
NA
NA
NA
NA
Red nucleus
NA
NA
NA
↑
0.002
265
↑
0.02
465
Thalamus
NA
NA
NA
—
0.81
182
—
0.94
306
White matter
NA
NA
NA
—
0.07
117
—
0.93
211
Table 2. A summary of changes in brain iron levels of PD patients based on the current meta-analysis. ↑Increased iron level in PD. — No change of iron level in PD. NA, no data available. aAnalysis was removed.
Imaging of Iron
R2/R2* relaxometry (with better results obtained using R2 5-7) and,
susceptibility-weighted imaging (SWI).
quantitative susceptibility mapping (QSM)
{Wang, 2016 #1591} metaanalysis
Table 2. A summary of changes in brain iron levels of PD patients based on the current meta-analysis. ↑Increased iron level in PD. — No change of iron level in PD. NA, no data available. aAnalysis was removed.
{Pyatigorskaya, 2020 #1590} metaanalysis, 대개 early PD (table1)
SWI: 10-20% increase in SN PD (Table 3, ), effect size correlated positively with UPDRS values (r = -0.84,
QSM: , -30% increase in SN PD, (Table 9), QSM values correlate with UPDRS values (r = 0.57)
CRIticism
Both R2 and SWI are varible across studies.
SWI is a qualitative method.
QSM: The variability of susceptibility measurements was lower than that for SWI; however, the variability was still high, suggesting that more work needs to be done to standardize QSM image processing pipelines between cohorts. While advanced processing pipelines for QSM are not yet fully standardized,
IT
TEAMS
[Video problem] put in the below in the search box ( %appdata%¥Microsoft¥Teams
%appdata%\Microsoft\Teams
Transfer of Okta authorization* and installation of some application through Comp Portal App are required. Please check BOYD below. You may visit AskIT for set up if necessary.
I am trying to use my extra-monitor for my pc. I have purchased a usb to HDMI cable adaptor. ad I have downloaded the driver for the cable. So I want to install it to enable the adaptor. when you install it is asking for the admin credentials?
PRC1 narrative의 clinical plan 을 정식으로 일할래? Including SSE
Which components of the MDS-UPDRS III show the largest effect size with regard to progression?
Hardy
recording 에서 45분께,
lyso and mito are competitive substrates of lysosome
is limited to SN because oxidative stress of dopamine metabolism
mine (DA) metabolism itself is strongly linked to oxidative stress as its degradation generates ROS) and DA oxidation can lead to endogenous neurotoxins
as some DA derivatives show antioxidative effects.²
me: general problem (eg. Cortex), GBA goes to cortex
RS subtyping: everyone is mixture of lysome mitochondira, continuous distribution, not cleanly separated
ased microglia generation from fibroblast (DRI?)
Uncertain Spans
location
transcription
uncertainty
Wang 2016 #1591 metaanalysis sub-table / Substantia nigra second sub-row
the second sub-row reads ↑^a / 0.004 / 161, ↑^a / <10⁻⁵ / 556 with no third-column SWI value visible; preserved verbatim.
low confidence on whether the SWI cells in the second Substantia nigra sub-row are intentionally empty or clipped.
IT TEAMS sub-table / GraphPadPrism row
reads GraphPadPrism, / o / O (lowercase o in 기설치 column vs uppercase O in AskIT column); preserved verbatim.
low confidence on whether the case difference is intentional.
IT One AT TCAL / Temporary Local Admin link
the AskIT URL is partly clipped at the right edge (https://takeda.service-now.com/AskIT?id=nr_sc_cat_item&sys_id=4e9a33164fea1a006c73c5d0210cf42); the visible portion is reproduced and may not be reachable as-is.
URL fragment clipped; partial.
IT GraphPad Prism license / serial number
reads serial number GPS-1226021-RWF-####, until 20230528; the #### token is preserved as a placeholder for redacted digits visible in the source.