Parkin
This generated page lists source notes whose first nav_path entry slugifies to parkin. Two raw nav-root spellings collapse here: Parkin and the typo variant Parkin, (trailing comma carried from the Word document). The original nav-root spelling is preserved per row.
Sources whose first nav root is the longer PARKN GT (Takeshi Hioki, PFR-4249-100) are indexed separately at PARKN GT (Takeshi Hioki, PFR-4249-100).
| source | nav root | nav path | headings |
|---|---|---|---|
| 20240722_181855 | Parkin | Parkin > Parkin protein > KO Parkin | Parkin Protein; Concentration Of Parkin Protein; Commercial Parkin Product; ADDP In-Stock Parkin Proteins; Homology Of Parkin Protein; … |
| 20240722_181859 | Parkin | Parkin > Parkin protein > Location / States / Structure / Substrates transition | Parkin Protein Location, States, Structure, Mutations, And Substrates Transition; Location Of Parkin Protein; States Of Parkin Protein; Parkin Activation State Diagram; Substitutions, Deletions, And Multiplications Map; … |
| 20240722_181903 | Parkin | Parkin > Parkin protein > Substrates (& function) of Parkin > Parkin PD | Parkin Substrates, Animal Models, And Parkin-PD Prevalence; Substrates And Functions Of Parkin; Parkin PD - Prevalence Opening Note; Animal Models Of Parkin PD; Prevalence Of Parkin Mutations; … |
| 20240722_181907 | Parkin | Parkin > Parkin PD > Clinical strategy > Natural Hx study | Parkin-PD Prevalence And GE/GMS Biomarker Cohort Proposal; Prevalence Of Parkin Mutations; Young-Onset Combined Estimate; Late-Onset Estimate; Targeting And Rare-Disease Note; … |
| 20240722_181910 | Parkin | Parkin > Parkin PD | GE/GMS Participant Mutation Table and MP-PD Parkin Variant Reanalysis; Preceding Application / Ethics Fragment; GE/GMS Participant Mutation Table; GE/GMS Participant Sample Matrix; Sample Collection Requirements; … |
| 20240722_181914 | Parkin, | Parkin, > Parkin PD | PRKN Variant Carrier Tables And Clinical Characteristics; PRKN Variant Table Continuation; N LoF + Deleterious Missense Carriers (AMP-PD); Page, 2020 #1751; Table 2. Demographic And Clinical Characteristics; … |
| 20240722_181917 | Parkin, | Parkin, > Parkin PD | PRKN Clinical Characteristics And Pathogenic Mutation Evidence; Table 2. Demographic And Clinical Characteristics; PRKN Exon / Domain Variant Map; [Uncertain]ski, 2012 #692; Systematic Review / ROPAD Notes; … |
| 20240722_181921 | Parkin | Parkin > Parkin PD | PRKN Variant Annotation And Functional Assay Evidence; PRKN Variant Annotation Table, Continuation; Figure 1: Parkin Missense Variants Functional Alterations; Parkin Variant Functional Assay Table; ACMG-AMP Clinical Evidence Criteria Note; … |
| 20240722_181925 | Parkin | Parkin > Parkin PD | PRKN Variant Classification Criteria And Portugal ARJP Mutation Summary; PRKN Variant Annotation Continuation; ACMG-AMP / Yi Pathogenic vs Benign Criteria; Summary For Clinical Trial From Yi; Masten 2018 Systematic Review / MDSGene Frequency; … |
| 20240722_181928 | Parkin, | Parkin, > Parkin PD | Portugal ARJP Table And Parkin Review Evidence; Table 1. Portugal ARJP Molecular Diagnosis; Klein, 2012 #915 Review; Akhit, 2016 #1061; Darvish, 2013 #1349, Iran; … |
| 20240722_181932 | Parkin | Parkin > Parkin PD | Korean YOPD / PRKN ClinVar And OMIM Allelic Variant Notes; Korean YOPD / PARK2 Mutation Frequency Notes; ClinVar / OMIM PRKN Allelic Variants; Brain Net / ClinVarMiner / Structural Variant Notes; Uncertain Spans |
| 20240722_181936 | Parkin | Parkin > Parkin PD | PRKN HGVS, dbSNP, And ClinVar Variant Tables; HGVS And dbSNP Variant List; ClinVar-Style PRKN Variant Rows; Uncertain Spans |
| 20240722_181939 | Parkin | Parkin > Parkin PD | ClinVar PRKN Variant Rows And Heterozygous PRKN Mutation Risk Notes; ClinVar-Style PRKN Pathogenic Variant Rows; Heterozygous Parkin Mutation; Uncertain Spans |
| 20240722_181943 | Parkin | Parkin > Parkin PD | PRKN Heterozygous Carrier Frequency, EOPD Risk, And Neuropathology; Heterozygous PRKN Carrier Notes; EOPD-Only Carrier Analysis; Population Estimates And Penetrance; Neuropathology Notes; … |
| 20240722_181947 | Parkin | Parkin > Parkin PD | PARKIN Autopsy Reports And PRKN-Related Clinical Phenotype Notes; Regional Neuronal Loss And Gliosis; Schneider 2017 PARKIN Autopsy Reports; Clinical Phenotype Notes; Alcalay 2014 EOPD PARKIN Cognitive/Demographic Table; … |
| 20240722_181950 | Parkin | Parkin > Parkin PD | Parkin PD Imaging Progression And Treatment Response; Carryover Notes Above The Imaging Section; Longitudinal Progression; Imaging Notes; Ribeiro 2009 Cross-Sectional Imaging; … |
| 20240722_181954 | Parkin | Parkin > Parkin PD | Parkin/PINK1 Mitophagy Evidence And pS65-Ub Detectability Notes; Parkin/PINK1 Mitophagy Evidence Matrix; Pathologic Row / Park2 Mutation; Extracellular Mitochondrial Expulsion Figure; Evidence Rows; … |
| 20240722_181958 | Parkin | Parkin > Parkin PD > pS65-Ub | pS65-Ub Postmortem Evidence, NBB Comparison, And Assay Development Notes; Hou 2018 p-S65-Ub Aging And LBD Figures; Summary Table; Hou 2018 Reduced Or Absent p-S65-Ub Staining Figure; Shiba-Fukushima 2017 Phospho-Ub IHC Note; … |
| 20240722_182001 | Parkin | Parkin > Parkin PD | Parkin Biomarker Strategy And Fibroblast Mitochondrial Evidence; Ubiquitin Linkage Basics; Biomarker Discovery And Validation Questions; pS65-Ub, Parkin Substrates, TE Biomarker, And Patient Selection; Fibroblast Mitochondrial Function Rationale; … |
| 20240722_182004 | Parkin | Parkin > Parkin PD | Parkin/PARK2 Fibroblast And iPSC Mitochondrial Evidence; Zilocchi 2020 PARK2 Fibroblast Continuation; Zilocchi Mitochondrial Proteomics And PhRET Proposal; Koentjoro Mitophagy And Rescue Notes; mtDNA, ER-Mitochondria, And Fibroblast Rescue Literature; … |
| 20240722_182007 | Parkin | Parkin > Parkin PD | Parkin Fibroblast Translation Plan And Parkin Delivery Evidence; Fibroblast, Lipid, And iPSC Evidence; Translation Plan Fibroblast And Leukocyte Complex Activity; Translation Plan Fibroblast; Leukocyte; … |
| 20240722_182011 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-4249-100) | PARKIN GT Expression Timeline And Parkin Delivery Evidence; Parkin Gene/Protein Delivery In Vivo Continuation; iCP-Parkin Model Notes; Bian MPTP Mouse And p62/SQSTM1 Notes; PARKIN GT Executive Summary And Expression Timeline; … |
| 20240722_182014 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-…) > Executive summary | Parkin GT Executive Summary, Clinical Strategy, And GBA PET Rationale; Parkin GT Development Timeline And Preclinical Plan; AAV9-Parkin Expression Comparisons; Vectors Carrying Codon-Optimized PRKN cDNA; Human Parkin Protein In iPSC-DA; … |
| 20240722_182018 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-4249-100) > Clinical strategy | iCP-Parkin, USP30/NHP Plan, MitoCoP, And DBS+PRkn Strategy; GBA PET Rationale Carry-Over; GBA Expression Evaluation By Imaging; Competitor Table: iCP-Parkin And USP30/NHP Plan; Cellivery Therapeutics / iCP-Parkin; … |
| 20240722_182021 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-4249-100) | PARKIN GT Decision Tree, Draft Timeline, Biomarker Matrix; Clinical Trial Endpoint Continuation; Decision Flow Notes; PARKIN GT Decision Tree; Draft Timeline; … |
| 20240722_182025 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-4249-100) | PARKN GT PRC1 Dataset, FXN Benchmark, In-Vivo Models, KOL Notes; Parkin KO Mice Biomarker Matrix Continuation; PRC1 In-Vivo Disease-Relevant / Function Model Dataset; Model Establishment In Parkin KO Mice Compared To WT Mice; Efficacy Study Of rAAV9-Parkin In Parkin KO Mice; … |
| 20240722_182029 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-4249-100) | PARKIN GT Biomarker Plan, KOL Notes, And Natural History Meeting Notes; Prior Table Continuation And IP Filing; KOL Notes: Hattori, Michael Schlossmacher, Christein Klein; Hattori; Michael Schlossmacher; … |
| 20240722_182033 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-4249-100) > Natural Hx study > Sample size estimation | MC1 PET / PRKN Natural History Study Proposal And Sample Size Estimation; MJFF / PPMI / Leuven MC1 PET Proposal Notes; Eberling / Timeline Fragment; Dated Notes; PRKN Longitudinal Observational Study Proposal; … |
| 20240722_182036 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-4249-100) > Natural Hx study > Sample size estimation > NHP Studies > Current plan | Sample Size Estimation And NHP Studies Current Plan; Cohort / ClinGen Continuation; Sample Size Estimation; 90% Power / One-Sided p-value < 0.05; 80% Power / One-Sided Alpha = 0.10; … |
| 20240722_182040 | Parkin | Parkin > PARKN GT (Takeshi Hioki, PFR-4249-100) > NHP Studies > Current plan | NHP Studies Current Plan, CSF Sampling, And Parkin Correlation Evidence; NHP Studies: Current Plan; Study Columns / Timeline; AAV / Route / Criteria Notes; Pilot / Device Notes; … |
| 20240722_182113 | Parkin, | Parkin, > TM > Assays > IVC > Parkin activity assay? > TMQB > TPP/TCP > Unmet Needs > Vector production > PINK-1 | Parkin; pS65-Ub assays; IVC; Parkin activity assay?; TMQB; … |