A FY21 draft allocation
- Strategic DDU budget for Pre-LG projects
- Strategic DDU budget for Post-LG projects
- KPI-linked Small Molecule project
- KPI-linked HDO project
- KPI-linked GT project
- Fundamental License
- Fundamental Consignment - Others
- Fundamental Consignment - Chem CRO FTE
- Fundamental Other Material
- Fundamental Basic Material
B. KPI-linked projects and tentative budget
| Category | Project | Tentative Budget size (Mainly bio/TM budget) |
|---|---|---|
| HDO project | HTT MAPT SNCA OMA1 DMPK Other new programs | 3.0 OKY |
| GT project | FXN GT GBA PD GT NG mHTT GT Parkin GT StrideBio #2  Heidelberg-related | 1.5 OKY |
| KPI-linked Small Molecule project (PE to CS) | IP6Ks Inhibitor | 0.6 OKY |
| HTT splicing Modulator | 0.9 OKY | |
| MAP4K4-Ferro Inhibitor | 0.9 OKY | |
| G4 Oral OX2R Agonist BU | 0.6 OKY | |
| KPI-linked Small Molecule project (LG to PE) | PKR Inhibitor | 0.5 OKY |
| NLRP3 Inhibitor | 0.5 OKY |
| NSTM | 0.96 OKY |
| NSTM-MBM material | $360,000 |
| GT whole | 1.5 OKY |
| 5 mil yen, = $50,000 |
Kamiguchi’san’s group: Our group may obtain around $350K fundamental budget that can cover almost of our group assay development cost(assay kit, reagent, Ab, etc..).
C FY21 draft allocation by Unit/Labs
- Strategic DDU budget for Pre-LG projects
- Strategic DDU budget for Post-LG projects
- KPI-linked Small Molecule project
- KPI-linked HDO project
- KPI-linked GT project
- Fundamental License
- Fundamental Consignment - Others
- Fundamental Consignment - Chem CRO FTE
- Fundamental Other Material
- Fundamental Basic Material
NSTM:
- Project leader of KPI related project (shown below, also see attached) will ask you to list up NSTM activity budget. Please provide the information. There is a cap, please discuss which item should be chosen. You can request buy-up if you need.
- If the translational tool is applicable for multiple targets, it will be allocated to most relevant or most advanced project budget.
- Budget for Non-KPI related program (not listed below, including in-kind contribution for partnership program) should be managed by NSTM fundamental.
- Those are listed up to the link to FY21 NS-TM FMCL
- Timeline: Oct 30.
- Ask Tim
- ASK Misa
- Parkin MBM 들이 Parkin-gt specific?
- 애매할대 어떻게?
- ASK Ootake
- GBA MBM 들은 gba activator 와 gba-gt 어떻게 구분?
- 애매할대 어떻게?
- MC1 어덯게 처리?
- Fy21에 payment 있을가? 2021.03 까지는 PET 임상 PAY있겠지.
- ParkinGT specific? Cgas는 미행당임.
- Mito CoP 해당가능할까?
- 될수있으면 NSTM에 넣자!
- Question to Sakamo: why no GBA activator? Non-KPI related program 에 있나?
- Is there Mito CoP?
- PLR
- capex
화환산 (currency conversion)
| KRW | ¥ | $ | ||||
|---|---|---|---|---|---|---|
| 40,000 | 4 만원 | 4,000 | 40 | |||
| 400,000 | 40 만원 | 40,000 | 400 | |||
| 4,000,000 | 400 만원 | 400,000 | 4,000 | |||
| 40,000,000 | 4 천만원 | 4,000,000 | 4 mil | 40,000 | 40 K | |
| 400,000,000 | 4 억 | 40,000,000 | 40 mil | 0.4 OKY | 400,000 | 400 K |
| 4,000,000,000 | 40 억 | 400,000,000 | 400 mil | 4 OKY | 4,000,000 | 4 mil |
| 40,000,000,000 | 400 억 | 4,000,000,000 | 4 Bil | 40 OKY | 40,000,000 | 40 mil |
Glossary
- polymorphic : a genetic locus with a wild type allele that is present less than 99 percent of the time ( the rest of the alleles being mutant)
- Nucleic acid: 여러 개의 nucleotides 모인 chain
Nucleotides 간의 연결은 covalent bond,
맞은 편 strand 간의 base 의 연결은 hydrogen bond - Neucleotides :
| Neucleotides의 세 구성 | |
|---|---|
| A phosphate | |
| sugar | Ribose (RNA경우) or Deoxyribose (DNA 경우) |
| Base (한 사람에 30억개) | A (adenine): purine C (cytosine): pyrimidine G (guanine): purine T (thymine): pyrimidine |
Nucleotide Base Codes
The nucleotide base codes that are used with the International Nucleotide Sequence Database is as follows. Sequence data is expressed with small letters only. Capital letter will be automatically converted to small letter.
| Symbol | Meaning | Explanation |
|---|---|---|
| a | adenine | |
| c | cytosine | |
| g | guanine | |
| t | thymine in DNA; uracil in RNA | |
| a or c | amino | |
| a or g | purine | |
| a or t | ||
| k | g or t | keto |
| v | a or c or g | not t |
| h | a or c or t | not g |
Uncertain Spans
| location | transcription | uncertainty |
|---|---|---|
IUPAC Nucleotide Base Codes table, upper rows (a / c / g / t / a or c / a or g / a or t) | Symbol column rendered empty | The Symbol column is structurally present in the source but the letter glyphs for these rows are too small/light in the available crops to confirm letter-by-letter; rendered empty rather than inferred. |
IUPAC Nucleotide Base Codes table, between a or t and g or t rows | rows for s (g or c) / y (c or t) not transcribed | The standard IUPAC ordering would place s and y here, but the visible band on this photo goes directly from a or t (top of the second header sub-block) to k / v / h (in the statusbar bleed); no s or y rows are legibly captured in any tile crop on this photo. The next photo (20240722_184854) opens at d / b / n, so any s / y rows are either present in a non-visible band of this page or omitted in the source. |
Currency conversion table, 4 천만원 cell | 4 천만원 | Apple Vision OCR reads this cell as 4 전반원; the visible glyphs in the body crop align with the standard Korean numeric label 천만원 (= 10,000,000 won) given the row’s 40,000,000 KRW value, so the transcription follows the visual reading. |