(Inline figure: Mitochondrial respiratory chain complexes — Complex I (NADH dehydrogenase), Complex III (cytochrome c reductase), Complex II (succinate dehydrogenase), Complex IV (cytochrome c oxidase), Complex V (ATP synthase). Preserved as body_r01 evidence.)
(Inline figure: “Fig. 3. Model of inhibitory effects of respiratory chain complexes by BCPP compounds. BCPP compounds specifically inhibit NADH-driven proton transport by binding to MC-I.” Preserved as body_r01 evidence.)
below table 2016 Wirth
Table 1. Subunits of complex I.
| Homo sapiens | Bos taurus | Yarrowia lipolytica | Pierisma thermophila | Paracoccus denitrificans | Escherichia coli | Comment | Module |
|---|---|---|---|---|---|---|---|
| NDUFS1 | 75-kDa | NUAM | |||||
| NDUFV1 | 51-kDa | NUBM | |||||
| NDUFS2 | 49-kDa | NUCM | |||||
| NDUFS3 | 30-kDa | NUGM | |||||
| NDUFV2 | 24-kDa | NUHM | |||||
| NDUFS8 | TYKY | NUIM | |||||
| NDUFS7 | PSST | NUKM | |||||
| NU1M | ND1 | NU1M | |||||
| NU2M | ND2 | NU2M | |||||
| NU3M | ND3 | NU3M | |||||
| NU4M | ND4 | NU4M | |||||
| NU5M | ND5 | NU5M | |||||
| NU6M | ND6 | NU6M | |||||
| NULM | ND4L | NULM | |||||
| NDUFA2 | B8ᵇ | NI8M | |||||
| NDUFS4 | AQDQ/18-kDa | NUYM | |||||
| NDUFS6 | 13-kDa | NUMM | |||||
| NDUFA12 | B17.2 | N7BM | |||||
| NDUFA7 | B14.5a | NUZM | |||||
| NDUFA5 | B13 | NUFM | |||||
| NDUFA9 | 39-kDa | NUEM | |||||
| NDUFA6 | B14 | NB4M | |||||
| NDUFAB1 | SDAP | ACPM1 / ACPM2 | |||||
| NDUFA1 | MWFE | NIMM | |||||
| NDUFA3 | B9 | NI9M | |||||
| NDUFA8 | PGIV | NUPM | |||||
| NDUFA11 | B14.7 | NUJM | |||||
| NDUFA13 | B16.6 | NB6M | |||||
| NDUFS5 | PFFD/15-kDa | NIPM | |||||
| NDUFB3 | B12 | NB2M | |||||
| NDUFB4 | B15 | NB5M | |||||
| NDUFB7 | B18 | NB8M | |||||
| NDUFB8 | ASHI | NIAM | |||||
| NDUFB9 | B22 | NI2M | |||||
| NDUFB10 | PDSW | NIDM | |||||
| NDUFB11 | ESSS | NESM | |||||
| NDUFV3 | 9-kDa | ||||||
| NDUFC1 | KFYI | ||||||
| NDUFC2 | B14.5b | ||||||
| NDUFA10 | 42-kDa | ||||||
| NDUFB1 | MNLL | ||||||
| NDUFB2 | AGGG | ||||||
| NDUFB5 | SGDH | ||||||
| NDUFB6 | B17 | ||||||
| NUXM | |||||||
| NEBM | |||||||
| NUNM | |||||||
| NUUM | |||||||
| ST1 | |||||||
NDUFS8, NDUFS7, NDUFS6, NDUFA13, NDUFB8 are highlighted in the source.
MAM (Mitochondria-associated membranes)
- RESOUrce
- {Veeresh, 2019 #1298}
(Inline figure: Paradigm of ER-mitochondria contacts. ER membrane protein MFN1, ER cytosolic protein MMM12, mitochondrial outer membrane MFN2, MMM10/Mdm10 are involved in Ca2+ and phospholipid homeostasis, mitophagy, mitochondrial dynamics, mitochondrial DNA maintenance and inheritance, and lipid protein import. Components labelled: CNX, BIP, GTP/SO1R, MFN1/MFN2, IP3R, GRP75, VDAC, PACS2, Gem1, Mmm1, Mdm10, Mdm12, Mdm34, VAPB, PTPIP51. Preserved as body_r03/body_r04 evidence.)
Imaging of MAM
| Tracer | Receptor | Cohort | Reference | Result |
|---|---|---|---|---|
| [¹¹C]SA-4503 ([¹¹C]SA-4503 mentioned earlier) | σ-1 receptor | HV (N=12) First report in human, | {Mansur, 2018 #876} | (Inline FIGURE 4 "Distribution of regional V_T estimates" — V_T (mL·cm⁻³) y-axis, Regions of interest x-axis: Cerebellum / Brainstem / Substantia nigra / Thalamus / Ventral striatum / Caudate / Putamen / Hippocampus / Insular cortex / Temporal lobe / Parietal lobe / Frontal cortex / Cerebellum. Three tracers: ¹⁸F-BCPP-EF, ¹¹C-SA-4503, ¹¹C-UCB-J. Preserved as body_r05 evidence.) Highest uptake in striatum, ↓ signal with age, suggesting that striatal mito density could be particularly susceptible to aging |
| sPD patients N=12 early PD (disease duration <2y) & ... | {Wilson, 2020 #902} MIND-MAPS https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/mind-maps-pd/ | (Inline (B) C[¹¹]SA-4503 V_T bar chart by region; preserved as body_r05 evidence) |
Uncertain Spans
| location | transcription | uncertainty |
|---|---|---|
| Subunits of complex I, NDUFA9 row | 39-kDa / NUEM | The “39-kDa” matches both the Bos taurus column and a Homo sapiens NDUFA9 entry; transcription assumes the standard mapping. |
| Veeresh figure caption | Pierisma thermophila | Likely the genus Pichia or Yarrowia / Pierisma; the species name is small. |
| Imaging row | [¹¹C]SA-4503 mentioned earlier | The exact receptor target column may include additional radioligands cropped from the right of the table. |
| MAM components list | Mdm10 / Mdm12 / Mdm34 / Mmm1 | Yeast-mitofission proteins; small-cap labels are partly illegible. |