Cognition / Motor+cog / NfL tail, Progression summary, MRI GBA, Leocadi 2022, Thaler 2018, Agosta 2013
Progression summary
| measure | difference | citation | stage | cohort |
|---|---|---|---|---|
| MOCA | 45% faster | (Ren, 2023 #2657) | Early+Mid | China |
| MOCA | = | (Caminiti, 2022 #2706) | Early | PPMI |
| MOCA | 18% faster | (Caminiti, 2022 #2706) | Mid (after y6) | PPMI |
| UPDRS total | 22% faster | (Caminiti, 2022 #2706) | Early | PPMI |
| UPDRS II | 33% faster | (Maple-Grødem, 2021 #2654) | Early | Europe |
| UPDRS III | 40.9% faster | (Maple-Grødem, 2021 #2654) | Early | Europe |
| UPDRS III | 36% faster | (Caminiti, 2022 #2706) | Early | PPMI |
| UPDRS III | 40% faster | (Ren, 2023 #2657) | Early+Mid | China |
MRI GBA
longitudinal PPMI (Caminiti, 2022 #2706)
46 GBA-PD, 339 iPD (281 LO-iPD, 58 EO-iPD), 59 CTRL.
MOCA (Fig 2: only in the patients who has longitudinal data, n=22 GBA-PD; Tables in main article and suppl: all patient).
| group | measure | baseline | 2yr | 6yr | Rate of change from "2-yrs" to "6-yrs" visits | after 6 years |
|---|---|---|---|---|---|---|
| GBA-PD | MOCA | 26.9 (2.5) | 26.3 (3.7) s.table2 | 24.6 (6) s.table3 | -0.29 (0.87) | 10% were below the MoCA cut-off score of 26, with 1.63 MoCA points lost per year (0.29/1.63=18% faster임) |
| UPDRS total | 41.5 (12.6) | 43 (16.2) | 46.6 (17.7) | 1.03 (2.58) | ||
| UPDRS III | 28.9 (10.2) | 27.2 (8.9) | 30.4 (14.5) | 0.87 (2.24) | ||
| iPD | MOCA | 27.0 (2.3) | 25.7 (3.3) | 25.1 (4.5) | 0.08 (0.47) | 17% of patients were below the MoCA cut-off score of 26, with 1.34 points lost per year |
| UPDRS total | 38.0 (15.6) | 43.7 (16.2) | 41.3 (17.2) | 0.89 (2.12) | ||
| UPDRS III | 26.7 (12.2) | 28.0 (11.2) | 26.3 (12.0) | 0.94 (5.45) |
We found a significant correlation between low SUVr values in the thalamus at baseline and MOCA worsening from “2-yrs” to “6-yrs” follow-up visits in the early-iPD group (r = 0.996; P = 0.034).
MRI
ROI approach (volume cm³). Supplementary Table 1. ROIs structural volumes (cm³) at baseline (putamen, caudate, GP, thalamus, hippo, amygdala 등 이고 cortex는 없네!). baseline에서 이미 적음. And has GBA-PD vs iPD,
Longi/f/u는 ㄴ 없나? → CS와 collabo!: Cortical thickness data는 없나? Endpoint 도출 (total 가능?
datscan
GBA-PD patients showed a significantly lower DAT SUVr in the bilateral ventral striatum than HC and iPD.
Fig 3. Baseline: GBA-PD patients showed a significantly lower DAT SUVr in the bilateral ventral striatum than HC and early-iPD and late-iPD. The GBA-PD group showed a significantly lower 123I-FP-CIT SUVr in the whole contralateral putamen, anterior and motor putamen, globus pallidus, hippocampus, and amygdala than the early-iPD group.
[longi] From baseline to “2-years” follow-up, we found that the GBA-PD showed a global SUVr rate of change (i.e., mean rate of change of all considered ROIs) equal to 0.11, early-iPD equal to 0.09, and late-iPD equal to 0.16 (Fig. 4). The late-iPD group showed the highest global SUVr rate of change. Of note, we found that the early-iPD and late-iPD groups significantly increased their SUVr rate of change, namely significant SUVr reductions over time, in the ventral striatum in comparison with the GBA-PD group at “2-years” (early-iPD vs. GBA-PD P = 0.024; late-iPD vs. GBA-PD P < 0.001). 더 빠른 진행 X
The linear regression model revealed that low SUVr values in the caudate nucleus (motor division) at baseline were associated with UPDRS-III motor scores worsening from “2-years” to “6-years” follow-up visits in the whole PD patients (B = 6.46; P = 0.021) and in the late-iPD group (B = 10.26; P = 0.009). In the whole PD group (385 patients).
Baseline: GBA-PD = “cortical thinning of left temporal, parietal, and occipital gyri (vs. CTRL and iPD)
Leocadi 2022 #2708 (Italy)
Ten GBA-positive and 20 GBA-negative PD patients,
UPDRS O, MMSE O, MOCA X, Digit Span test etc O
Longi: GBA-PD = “cortical thinning of posterior regions, frontal and orbitofrontal cortices; similar pattern of subcortical, hippocampal, and amygdala volume loss (vs. iPD), whereas the pattern of subcortical GM volume (caudate, pallidum, putamen, thalamus, hippo, amygdala) atrophy ( was similar in the two PD group
Js: MMSE 도 mri 도 모두 no longi change and no difference between GBA-D and Non-GBA-PD (early PD 라 그럴것임)
Cortical thickness and Sub-cortical Volume
| cohort | finding | |
|---|---|---|
| cross-sectional | (Thaler, 2018 #2709) Tel-Aviv Medical Center. 12 GBA-PD, 9 LRRK2-PD, 57 iPD, 14 GBA-NMC, 41 LRRK2-NMC, 49 CTRL | Cortical thickness and Sub-cortical Volume no differences in GM have been reported between GBA-PD, PD with LRRK2 mutations (LRRK2-PD), and iPD, although,, lower GM volumes were reported in bilateral hippocampus, nucleus accumbens, caudate, thalamus, putamen and amygdala, and the right pallidum in patients with PD (eg, GBA-PD, LRRK2-PD, and iPD) compared to unaffected participants (eg, GBA-NMC, LRRK2-NMC, and controls). |
| cross-sectional | (Agosta, 2013 #2710) Christine Klein, Serbian PD patients a; 15 GBA-PD, 14 iPD, 16 CTRL | no differences in GM have been reported between GBA-PD, iPD, and controls20 |