| analyte / sample | citation | GBA-PD+ Direction | n | GBA+PD+ Direction | n |
|---|
| GBA protein / Brain | (Gundner et al., 2019) | ↓ trend (cortex, putamen, SN) | | ↓ (~39%) DIFFERENTIATED FIG S3 | 10 (hc 15) |
| GBA protein / Brain | (Gegg et al., 2012) | ↓ | | ↓ fig2a : 46-70% reduction, the mean is 57.4% | 12-14 (hc 6-10) |
| GBA protein / Brain | (Murphy et al., 2014) | ↓ (38%, ant cingulate cortex), = in occipital cortex | | Not done | |
| GBA protein / CSF | (Mullin et al., 2020, Ambroxol trial, LCMS) | | 9 | HC 대비 자료 X (꽤 ↓ than GBA-PD) | 8 |
| GBA activity / Brain | (Gundner et al., 2019) | ↓ trend (-~10%) cortex, putamen), = (SN) | ~30 | ↓ (23.8%, certainly not differentiated) fig S3 | 10 |
| GBA activity / Brain | (Gegg et al., 2012) | ↓ (-20-30%, SN, cerebellum, putamen) | 14 | ↓ (-20-60%, SN, cblllti, putamen) | 14 |
| GBA activity / Brain | (Nelson et al., 2018) | ↓ (only in H&Y4, temporal cortex) | 48 | ↓ | 2 |
| GBA activity / Brain | (Huebecker et al., 2019) | SN: ↓ (-30%) | 7 | ↓ | 3 |
| GBA activity / Brain | (Chiasserini et al., 2015) | ↓ (-14%, SN), ↓ (-20%, Caudate), =(cortex, hippocampus, cerebellum, putamen) | 26 | | |
| GBA activity / Brain | (Murphy et al., 2014) | ↓ (-27%) | 19 | | |
| GBA activity / Brain | (Leyns, 2022 #2182) | 시간없어 확인 안 했음. | | ↓ by 39% | 72 (16 PD, 56 PDD, note:) |
| GBA activity / Brain | (Rocha et al., 2015) | ↓ (-30-50%, hippocampus, cerebellum) = (cortex) | 23 | | |
| GBA activity / CSF | (Schondorf et al., 2014) | = | 15 | ↓ (-50%, fig7a, age-matched HC 대비 differentiate 되는 듯 보임.) Visual estimation: 700 vs 350 | 15 |
| GBA activity / CSF | (Parnetti et al., 2017) | ↓ (-25%) | ~70 | ↓↓ (-50%, fig3a, quatile2&3 로는 differentiate 보이지만, 95% PI 로는 분명 NOT-DIFFERENTIATED) | 10 |
| GBA activity / CSF | (Balducci et al., 2007) | ↓ | 12 | | |
| GBA activity / CSF | (Mullin et al., 2020, Ambroxol trial) | | 9 | 꽤 ↓ than sPD (but HC 대비 data 없을 것 같아) | 8 |
| GBA activity / CSF | (Parnetti, 2014 #835) | ↓ | ~70 | | |
| GBA activity / CSF | (Oftedal, 2023 #2655) | ↓ (17.4%) | 105 | ↓↓ (23.1%, but NS vs GBA-PD) | 12 |
| GBA activity / DBS | (Alcalay et al., 2015) | ↓ (6%, 11.85 vs 11.14) | 517 | ↓ (-33%) | 81 |
| GBA activity / DBS | (Omer, 2022 #2659) Biogen | = (4.77 vs 4.85) | 30 | ↓ (21%, ie 3.15 vs 4.85) | 102 |
| GBA activity / DBS | (Huh et al. 2020, PMID 32540937) HBS-1, HBS2, PDRP | = | A lot! | | |
| GBA activity / DBS | (Alcalay et al. 2020, PMID 32888397) PPMI, MS/MS | = | 392 | | |
| GBA activity / DBS | (Lerche et al. 2021, PMID 33547828) PPMI 이거 대신 바로 위 Alcalay 2020 쓰자 (단위이상, % substrate degradation) | = | 277 | | |
| GBA activity / blood | (Lerche, 2021 #2575) PPMI) | = | 277 | ↓ (29%, 11.78 vs 8.35) | 31 |
| GBA activity / Monocyte | (Atashrazm et al., 2018) | N=39) GCase activity was significantly reduced in monocytes, | | GBA activity: N=9) ... | |
| GBA activity / PBMC | (Papagiannakis, 2015 #753) | = | | ↓ (js 40%), overlap 되는듯 (fig2D) | |
| GBA activity / blood | (Ortega, 2016 #851) Blood, GBA activity only | Can't know | 8 | ↓ | 15 |
| GlcCer / Brain | (Gegg et al., 2015) putamen | = | 5 | = (오히려 약간 ↓) | 5 |
| GlcCer / Brain | (Boutin et al., 2016) | ↑ (trend) | 26 | | |
| GlcCer / Brain | (Kurzawa-Akanbi 2021 #2577) Frontal and cingulate cortex, 10 controls | = | | = (Note: ↑ ceramides) | 21 (3 PD, 4 PDD, 14 DLB) |
| GlcCer / Brain | (Leyns, 2022 #2182) | 시간없어 확인 안 했음. | | ↑ (30%) | 72 (16 PD, 56 PDD, 14 DLB) (note: n of HC=70) |
| GlcCer / Brain | (Huebecker et al., 2019) | SN: ↑ (~1.5x) | 7 | | 3 |
| GlcCer / CSF | (Huh, 2021 #2538, PPMI) | = (N=227), (LC-MS/MS) | 227 | ↑ (18%, median, sig, but overlap) | 44 |
| GlcCer / CSF | (Lerche, 2021 #2575, PPMI) | ↑ (N=276) UPLC-MS/MS (6.42 vs 5.45), 같은 PPMI 인데 Huh 와 상이! | 276 | ↑ (21%, mean, sig but small d=0.28. 6.6±4.85 vs 5.45±3.18) | 31 |